Key result
Higher neutrophil to lymphocyte ratio was an independent predictor for the severity of coronary artery disease assessed by SYNTAX score in patients with STEMI (β = 0.277, P<.001).
Why the study?
Is the neutrophil to lymphocyte ratio associated with the severity of coronary artery disease (SYNTAX score) in patients with STEMI undergoing primary PCI?
Observational (n=840)
Is the neutrophil to lymphocyte ratio associated with the severity of coronary artery disease (SYNTAX score) in patients with STEMI undergoing primary PCI?
The neutrophil to lymphocyte ratio measured at admission is an independent predictor of coronary artery disease severity (SYNTAX score) in patients with STEMI undergoing primary PCI.
Should not yet change STEMI practice; hypothesis-generating for NLR integration into CAD severity models.
We assessed the relationship between the severity of coronary artery disease assessed by SYNTAX score (SS) and neutrophil to lymphocyte ratio (N:L ratio) in patients with ST elevation myocardial infarction (STEMI). In total, 840 patients with STEMI in whom primary percutaneous coronary intervention was performed were prospectively included (622 male, 218 female; mean age 58.6 ± 12.4 years). Total and differential leukocyte counts and other biochemical markers were measured at admission. Patients were categorized into tertiles on the basis of SS. The N:L ratio of SShigh group was higher compared with SSlow and SSmid groups (P < .001 for all). Multivariate regression analysis showed that N:L ratio (β = .277, P < .001), ejection fraction (β = -.086, P = .012), age (β = .104, P = .004), and diabetes (β = .152, P < .001) were the independent predictors for SS in patients with STEMI.
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Şahin et al. (2012) conducted an observational in ST-Segment Elevation Myocardial Infarction (STEMI) (n=840). Neutrophil to lymphocyte ratio (N:L ratio) was evaluated on Severity of coronary artery disease assessed by SYNTAX score (SS) (β = 0.277, p=<.001). Higher neutrophil to lymphocyte ratio was an independent predictor for the severity of coronary artery disease assessed by SYNTAX score in patients with STEMI (β = 0.277, P<.001).
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