Key result
A high neutrophil-to-lymphocyte ratio on admission was associated with a higher rate of in-hospital death compared to a low ratio in patients with acute STEMI.
Why the study?
Does a high neutrophil-to-lymphocyte ratio (NLR) predict in-hospital complications and mortality in patients with acute STEMI thrombolysed with streptokinase?
Observational (n=200)
No
Does a high neutrophil-to-lymphocyte ratio (NLR) predict in-hospital complications and mortality in patients with acute STEMI thrombolysed with streptokinase?
An elevated neutrophil-to-lymphocyte ratio at admission is a simple, cost-effective marker that independently predicts higher in-hospital morbidity and mortality in STEMI patients treated with streptokinase.
Answers are grounded in this paper and cite their sources.
High NLR may flag higher in-hospital risk after streptokinase in STEMI; leaves open incremental value over existing scores.
Introduction: Atherosclerosis is a inflammatory disease of arterial wall which have multifactorial causes.So study was done to investigate the role of neutrophil lymphocyte ratio in prediction of in hospital adverse events and mortality in ST elevated myocardial infarction (STEMI) patients thrombolysed with streptokinase (SK).Material and methods: A prospective comparative observational study is done in between April 2016 and october 2016, The study consisted of 200 patients [150 (75%) men, 50(25%) women, mean age 53 ± 10.6 years], diagnosed case of acute ST elevation MI.Patints were devided in two group according to NLR (High NLR and Low NLR) detected by CBC.Result: A Total of 120 cases developed complications;40 (20%) died in hospital.patients in high NLR groups had higher rate of complications (75% vs 25% p value .002)and death (80% vs 20%), p value.0004), in hospital than those in low NLR group.Conclusion: Our findings reveal that N/L ratio, a simple marker which can be derived from a routine complete blood count test was significantly and independently related to prognosis of Acute myocardial infarction.
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Gupta et al. (2018) conducted an observational in Acute ST segment elevation myocardial infarction (n=200). High neutrophil-to-lymphocyte ratio (>4.50) vs. Low neutrophil-to-lymphocyte ratio (≤4.50) was evaluated on In-hospital death (p=0.0004). A high neutrophil-to-lymphocyte ratio on admission was associated with a higher rate of in-hospital death compared to a low ratio in patients with acute STEMI.
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