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August 31, 2023International Journal of Research in Medical SciencesOpen Access

Association between neutrophil to lymphocyte ratio with the severity of coronary artery diseases

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Key result

A high neutrophil to lymphocyte ratio was independently associated with severe coronary artery disease (OR 3.308) in patients undergoing elective coronary angiography.

Why the study?

This study aimed to evaluate the association between neutrophil to lymphocyte ratio and the severity of coronary artery disease.

Does high neutrophil to lymphocyte ratio predict the severity of coronary artery disease in patients undergoing elective coronary angiography?

Population

160 patients undergoing elective coronary angiography with symptoms of coronary artery disease in Bangladesh

Comparison

Association between neutrophil to lymphocyte ratio and Gensini score

Design

Single-centre cross-sectional study

Authors

SDSaurav DasPDPrabir Kumar DasAAAnisul Awal

Discussion

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Overview

May support NLR in CAD risk assessment; leaves open prospective validation before clinical adoption.

Study Design

Type

Cross-Sectional (n=160)

Multicenter

No

Structured PICO

Does high neutrophil to lymphocyte ratio predict the severity of coronary artery disease in patients undergoing elective coronary angiography?

P
Population
160 patients aged 30 to 78 years undergoing elective coronary angiography for suspected coronary artery disease in Bangladesh.
E
Exposure
High neutrophil to lymphocyte ratio (NLR)
O
Outcome
Severity of coronary artery disease assessed by Gensini scoresurrogate

Main Result

Odds Ratio: 3.308 (95% CI 1.645–6.653)

p-value: p=0.001

High neutrophil to lymphocyte ratio is independently associated with angiographically severe coronary artery disease, suggesting its potential utility as a simple predictive biomarker.

Limitations

  • Small sample size from only one hospital
  • Randomization was not done
  • Other inflammatory biomarkers were not evaluated
  • Assessment of CAD severity was performed by visual estimation of coronary angiography
  • Study was conducted over a very short period

Cite This Study

Das et al. (2023) conducted a cross-sectional in Coronary artery disease (n=160). High neutrophil to lymphocyte ratio (NLR) vs. Low neutrophil to lymphocyte ratio was evaluated on Severe coronary artery disease (Gensini score ≥30) (OR 3.308, 95% CI 1.645-6.653, p=0.001). A high neutrophil to lymphocyte ratio was independently associated with severe coronary artery disease (OR 3.308) in patients undergoing elective coronary angiography.

synapsesocial.com/papers/6aa2ca596401f02f7be570ddhttps://doi.org/10.18203/2320-6012.ijrms20232768
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association between neutrophil to lymphocyte ratio and severity of coronary artery disease2018 · 4 citations
  2. 2Association between Neutrophil to Lymphocyte Ratio and Severity of Coronary Artery Disease in Chronic Stable Angina2018 · 4 citations
  3. 3Association Between Neutrophil to Lymphocyte Ratio and Severity of Coronary Artery Disease in Acute Myocardial Infarction Patients2024 · 2 citations
  4. 4Relation between neutrophil-to-lymphocyte ratio and severity of coronary artery stenosis2014 · 38 citations
  5. 5Relation of neutrophil-to-lymphocyte ratio with coronary artery disease severity in patients undergoing coronary angiography2022