Key result
MINOCA in very young patients is linked to a ~4-fold increase in long-term MACE.
Why the study?
The study was conducted to analyze the clinical features and outcomes of very young patients diagnosed with MINOCA.
Does a diagnosis of MINOCA affect the long-term risk of MACE compared to obstructive CAD or non-coronary disease controls in patients ≤40 years old?
Case-Control (n=408)
No
Does a diagnosis of MINOCA affect the long-term risk of MACE compared to obstructive CAD or non-coronary disease controls in patients ≤40 years old?
Hazard Ratio: 4.13 (95% CI 1.22–13.89)
p-value: p=0.010
Very young patients (≤40 years) with MINOCA have a similarly poor long-term prognosis as those with obstructive CAD, emphasizing the need for aggressive secondary prevention.
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MINOCA in patients ≤40 was associated with higher long-term MACE risk; leaves open whether targeted prevention improves prognosis.
Juan‐Salvadores et al. (2022) conducted a case-control in Myocardial infarction with non-obstructive coronary arteries (MINOCA) (n=408). Myocardial infarction with non-obstructive coronary arteries (MINOCA) vs. Non-coronary artery disease (controls) was evaluated on Major adverse cardiovascular events (MACE) (HR 4.13, 95% CI 1.22-13.89, p=0.010). Very young patients with MINOCA had a significantly higher risk of major adverse cardiovascular events at long-term follow-up compared to controls without coronary artery disease (HR 4.13).