BMP9 promotes peri-implant osseointegration in beagle defects

PURPOSE: efficacy of bone morphogenetic protein 9 (BMP9) relative to bone morphogenetic protein 2 (BMP2) in a beagle peri-implant critical-size defect model. METHODS: Peri-implant defects were created in beagle dogs and treated with either a collagen sponge (CS) or deproteinized bovine bone mineral with collagen (OCS-B Xenomatrix collagen [OCS-BC]), with or without BMP2 or BMP9. After 8 weeks, bone regeneration and osseointegration were evaluated using radiographic, histological, and biomechanical analyses. RESULTS: <0.0001). Two-way analysis of variance indicated scaffold-dependent magnitudes for bulk endpoints, whereas interaction terms were not significant for BIC, ROI-based osseointegration, or ISQ, supporting preservation of BMP9-associated benefits across scaffold types for these outcomes. CONCLUSIONS: BMP9 produced overall improvements comparable to BMP2 and may provide more reproducible osseointegration-related outcomes across scaffold types.