February 1, 2002Stroke
Progression of Middle Cerebral Artery Occlusive Disease and Its Relationship With Further Vascular Events After Stroke
Key result
Progression of middle cerebral artery occlusive disease at 6 months was associated with a higher risk of vascular events compared to stable or normalized arteries (38.5% vs 12.5% and 4.8%; P=0.004).
Why the study?
Does the progression of MCA occlusive disease assessed by serial TCD predict further vascular events in patients with symptomatic MCA stenosis or occlusion?
Population
143 consecutive patients with cerebral ischemia hospitalized with symptomatic middle cerebral artery…
Comparison
Serial transcranial Doppler ultrasound… vs Comparison among patients with normalized…
Design
Cohort
Follow-up
6 months
Authors
Discussion
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Implication
May support serial TCD for risk stratification in symptomatic MCA stenosis; leaves open whether modifying progression reduces events.
Study Design
Type
Cohort (n=143)
Structured PICO
Does the progression of MCA occlusive disease assessed by serial TCD predict further vascular events in patients with symptomatic MCA stenosis or occlusion?
P
Population
143 consecutive patients with cerebral ischemia hospitalized with symptomatic middle cerebral artery (MCA) stenosis (n=107) or occlusion (n=36).
I
Intervention
Serial transcranial Doppler ultrasound (TCD) examinations at baseline and 6 months to assess changes in MCA flow velocities (categorized as normalized, stable, or progressed).
C
Comparator
Comparison among patients with normalized, stable, or progressed MCA flow velocities.
O
Outcome
Occurrence of further vascular events (stroke or coronary events) during the 6-month period.composite
Main Result
Absolute Event Rate: 38.5% vs 4.8%
p-value: p=0.004
Progression of MCA occlusive disease on serial TCD is associated with a significantly increased risk of recurrent vascular events at 6 months.
Cite This Study
Wong et al. (2002) conducted a cohort in Symptomatic middle cerebral artery (MCA) occlusive disease (n=143). Progression of MCA occlusive disease (assessed by TCD) vs. Stable or normalized MCA was evaluated on Stroke or coronary events (p=0.004). Progression of middle cerebral artery occlusive disease at 6 months was associated with a higher risk of vascular events compared to stable or normalized arteries (38.5% vs 12.5% and 4.8%; P=0.004).