Key result
Submaximal cycling yields greater post-exercise microvascular reactivity than maximal cycling in healthy adults.
Why the study?
The effects of exercise intensity (maximal vs. submaximal) on NIRS-derived blood volume and microvascular reactivity in the acute post-exercise timeframe remained to be explored.
Does submaximal versus maximal cycling exercise improve post-exercise microvascular reactivity and skeletal muscle blood volume in healthy adults?
Does submaximal versus maximal cycling exercise improve post-exercise microvascular reactivity and skeletal muscle blood volume in healthy adults?
Submaximal, but not maximal, cycling exercise augments post-exercise microvascular reactivity in healthy adults, though both intensities increase skeletal muscle blood volume.
Submaximal cycling may augment post-exercise microvascular reactivity more than maximal in healthy adults; leaves open clinical translation and requires confirmation in patients.
Aim Skeletal muscle blood volume responds to the metabolic demands of exercise and augmented microvasculature reactivity. We sought to explore the effects of exercise intensity (maximal vs. submaximal) on near-infrared spectroscopy (NIRS)-derived blood volume and microvascular reactivity in the acute post-exercise timeframe. Methods Healthy individuals ( N = 18) between 18 and 35 years completed a vascular occlusion test (VOT) followed by a maximal cycling test. A second VOT was performed 15-min post-exercise. One week later, the protocol was repeated before and after a submaximal bout of cycling (60% VO 2 peak). NIRS was used to assess total hemoglobin (tHb) (i.e., blood volume) before, during, and after exercise, as well as muscle oxygen consumption (mVO 2 ) and microvascular reactivity (StO 2 % s −1 ) pre- and post-exercise. Results Compared with pre-exercise, tHb was elevated at the end of exercise ( p < 0.001) and remained elevated 15-min post-exercise ( p < 0.001) regardless of trial (combined means pre: 5.39 ± 0.82, during: 14.01 ± 1.73, and post-exercise: 10.89 ± 1.24 O.D.). mVO 2 was greater post-exercise in the max vs. submax trial (− 0.36 ± 0.12 vs. − 0.22 ± 0.11% s −1 ; p < 0.001). Compared with pre-exercise, microvascular reactivity was unchanged following the max trial (1.91 ± 0.61 vs. 1.71 ± 0.61% s −1 ; p = 0.079) but was greater following the submax trial (1.72 ± 0.43 vs. 1.98 ± 0.59; p = 0.007). Conclusion Cycling at a submaximal, but not maximal, intensity results in augmented post-exercise microvascular reactivity, while post-exercise increases in skeletal muscle blood volume were found regardless of exercise intensity.
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Landers‐Ramos et al. (2025) studied Healthy adults (n=18). Submaximal cycling (60% VO2 peak) vs. Maximal cycling test to exhaustion was evaluated on Post-exercise microvascular reactivity (reperfusion slope, % s-1) (d=0.449, p=<0.001). Submaximal cycling resulted in significantly greater post-exercise microvascular reactivity compared to maximal cycling (p < 0.001) in healthy adults.
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