In 1964 it was reported that specifically immune macrophages could destroy allogeneic target cells in vitro by a nonphagocytic mechanism (12). More recently, similar but nonimmunologic destruction of tumor target cells by activated macrophages has been described (1, 3). The present study demonstrates that activated macrophages from mice pretreated with CFA 7 weeks previously are cytotoxic to cells with abnormal growth characteristics in vitro. The results parallel those obtained with another system, activated macrophages from mice chronically infected with T. gondii (3).
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Hibbs et al. (1972) studied this question.