What question did this study set out to answer?

Characterize the molecular mechanisms governing the development and function of the blood-brain barrier by establishing a comprehensive transcriptomic profile of brain endothelial cells.

October 29, 2010PLoS ONEOpen Access

The Mouse Blood-Brain Barrier Transcriptome: A New Resource for Understanding the Development and Function of Brain Endothelial Cells

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Authors

RDRichard DanemanUniversity of San Diego LZLu ZhouHebei Medical University DADritan AgalliuColumbia University Irving Medical Center

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Implication

Transcriptomic analysis uncovers distinct molecular pathways and enriched transcripts in mouse brain endothelial cells, highlighting RXRalpha signaling in blood-brain barrier maintenance.

Key Points

Characterize the molecular mechanisms governing the development and function of the blood-brain barrier by establishing a comprehensive transcriptomic profile of brain endothelial cells.
Purified endothelial cells from mouse brain, liver, and lung tissues.
Performed comparative gene expression profiling to identify transcripts specifically enriched in blood-brain barrier endothelial cells compared to peripheral endothelial cells.
Identified distinct central nervous system endothelial transcripts, including novel tight junction proteins, transporters, metabolic enzymes, and previously uncharacterized signaling components.
Demonstrated specific enrichment of the RXRalpha signaling cascade in blood-brain barrier endothelial cells, implicating this pathway in barrier regulation.

Cite This Study

Daneman et al. (2010) studied this question.

synapsesocial.com/papers/6a1ddbc6ef3fa0b4c0ef7a46 https://doi.org/10.1371/journal.pone.0013741

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Implication

Transcriptomic analysis uncovers distinct molecular pathways and enriched transcripts in mouse brain endothelial cells, highlighting RXRalpha signaling in blood-brain barrier maintenance.

The Mouse Blood-Brain Barrier Transcriptome: A New Resource for Understanding the Development and Function of Brain Endothelial Cells

Discussion

Member takes

Implication

Key Points

Cite This Study

The Mouse Blood-Brain Barrier Transcriptome: A New Resource for Understanding the Development and Function of Brain Endothelial Cells

Discussion

Member takes

Implication

Key Points

Cite This Study

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