Observational (n=28)
No
Tropheryma whipplei endocarditis is an emerging clinical entity primarily affecting middle-aged and older men with arthralgia, requiring specific molecular diagnostics and prolonged antibiotic therapy.
T. whipplei endocarditis merits consideration in arthralgic older men; case reports leave open optimal therapy duration.
Tropheryma whipplei endocarditis differs from classic Whipple disease, which primarily affects the gastrointestinal system. We diagnosed 28 cases of T. whipplei endocarditis in Marseille, France, and compared them with cases reported in the literature. Specimens were analyzed mostly by molecular and histologic techniques.
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Fenollar et al. (2013) conducted an observational in Tropheryma whipplei endocarditis (n=28). Doxycycline and hydroxychloroquine was evaluated.
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