Key result
Second-generation cryoballoon ablation resulted in a significantly higher rate of chronic pulmonary vein isolation compared with first-generation cryoballoon (77% vs. 32%; P < 0.0001).
Why the study?
Does second-generation cryoballoon ablation improve the rate of durable pulmonary vein isolation compared to first-generation cryoballoon in patients with recurrent atrial tachyarrhythmia?
Population
Patients with recurrent atrial tachyarrhythmia undergoing a second procedure after initial pulmonary vein…
Comparison
Second-generation cryoballoon ablation vs First-generation cryoballoon ablation
Design
Cohort
Follow-up
192 (75:245) days
Authors
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Supports higher durable PVI with second-generation cryoballoon; extends observational data but should not yet change ablation practice.
Observational (n=206)
Does second-generation cryoballoon ablation improve the rate of durable pulmonary vein isolation compared to first-generation cryoballoon in patients with recurrent atrial tachyarrhythmia?
Absolute Event Rate: 77% vs 32%
p-value: p=< 0.0001
Second-generation cryoballoon ablation provides significantly higher rates of durable pulmonary vein isolation compared to first-generation devices, with the right superior pulmonary vein being most vulnerable to reconnection.
Bordignon et al. (2015) conducted an observational in Recurrent atrial tachyarrhythmia (n=206). Second-generation cryoballoon (CB2) ablation vs. First-generation cryoballoon (CB1) ablation was evaluated on Chronic pulmonary vein isolation rate (p=< 0.0001). Second-generation cryoballoon ablation resulted in a significantly higher rate of chronic pulmonary vein isolation compared with first-generation cryoballoon (77% vs. 32%; P < 0.0001).
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