Key result
Phenotype biomarkers and PPG-based monitoring offer more accurate, feasible hypertension management than standard care.
Why the study?
Susceptibility to complications and treatment response vary in hypertension, but available non-invasive blood pressure measurement techniques have inherent inaccuracy limiting precise personalized management.
Precision medicine in hypertension requires accurate blood pressure measurement, which may be improved by novel photoplethysmography-based techniques over traditional methods.
Personalized management of diseases by considering relevant patient features enables optimal treatment, instead of management according to an average patient. Precision management of hypertension is important, because both susceptibility to complications and response to treatment vary between individuals. While the use of genomic and proteomic personal features for widespread precision hypertension management is not practical, other features, such as age, ethnicity, and cardiovascular diseases, have been utilized in guidelines for hypertension management. In precision medicine, more blood-pressure-related clinical and physiological characteristics in the patient's profile can be utilized for the determination of the threshold of hypertension and optimal treatment. Several non-invasive and simple-to-use techniques for the measurement of hypertension-related physiological features are suggested for use in precision management of hypertension. In order to provide precise management of hypertension, accurate measurement of blood pressure is required, but the available non-invasive blood pressure measurement techniques, auscultatory sphygmomanometry and oscillometry, have inherent significant inaccuracy-either functional or technological-limiting the precision of personalized management of hypertension. A novel photoplethysmography-based technique for the measurement of systolic blood pressure that was recently found to be more accurate than the two available techniques can be utilized for more precise and personalized hypertension management.
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Nitzan et al. (2022) conducted a review in Hypertension. Precision medicine and photoplethysmography (PPG)-based blood pressure measurement vs. Standard hypertension management (auscultatory sphygmomanometry and oscillometry) was evaluated. Personalized hypertension management using phenotype biomarkers and novel photoplethysmography-based blood pressure measurement techniques offers a more feasible and accurate approach than current standard methods or genomic profiling.
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