November 3, 1989Science
Dominoes and Clocks: the Union of Two Views of the Cell Cycle
Authors
Discussion
Loading...
Member takes
Implication
Narrative review reveals conserved genetic and biochemical mechanisms driving mitosis across species, suggesting universal principles governing cell cycle transitions.
Key Points
- Synthesize recent genetic and biochemical findings to understand the regulatory mechanisms driving cell cycle transitions, particularly entry into mitosis.
- Literature review integrating experimental evidence from genetic and biochemical investigations of cell division.
- Comparative analysis evaluating the phylogenetic conservation of mitotic induction mechanisms across diverse eukaryotic species.
- Identification of evolutionary conservation in the molecular triggers and regulatory complexes that govern entry into mitosis.
- Reconciliation of sequential dependency ('dominoes') and autonomous biochemical oscillator ('clocks') models to explain eukaryotic cell cycle progression.
Cite This Study
Murray et al. (1989) studied this question.