Key result
Higher arterial stiffness, measured by aortic pulse wave velocity, was associated with larger white matter lesion volume (difference per SD increase 0.07; 95% CI, 0.02-0.12).
Why the study?
Is increased arterial stiffness associated with cerebral small vessel disease?
Population
1460 participants from a population-based study, mean age 58.2 years
Comparison
Higher arterial stiffness as measured by aortic… vs Lower arterial stiffness (aPWV)
Design
Cross-sectional
Authors
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Supports association in uncontrolled hypertension but should not alter practice; leaves open causality for cerebral small vessel disease.
Observational (n=1,460)
Is increased arterial stiffness associated with cerebral small vessel disease?
Effect estimate: Difference 0.07 (95% CI 0.02-0.12)
Increased arterial stiffness is associated with a larger volume of white matter lesions, particularly in individuals with uncontrolled hypertension.
Poels et al. (2012) conducted an observational in Cerebral small vessel disease (n=1,460). Aortic pulse wave velocity (aPWV) was evaluated on White matter lesion volume (Difference 0.07, 95% CI 0.02-0.12). Higher arterial stiffness, measured by aortic pulse wave velocity, was associated with larger white matter lesion volume (difference per SD increase 0.07; 95% CI, 0.02-0.12).