Key result
Systemic vascular resistance directly correlated with peak myocardial stress (standardized β=1.12; P<0.0001), and women demonstrated higher peak stress than men (534 vs 507 kdyne/cm2; P<0.0001).
Observational (n=1,214)
Effect estimate: standardized β 1.12
p-value: p=<0.0001
Different arterial properties have selective effects on time-resolved ejection-phase myocardial wall stress, and women demonstrate less efficient myocardial-arterial coupling compared to men.
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Indicates potential sex disparity in coupling efficiency; leaves open whether vascular-targeted therapies benefit women differentially.
Chirinos et al. (2012) reported an observational. Arterial properties (systemic vascular resistance, impedance, compliance) was evaluated on Peak myocardial stress (standardized β 1.12, p=<0.0001). Systemic vascular resistance directly correlated with peak myocardial stress (standardized β=1.12; P<0.0001), and women demonstrated higher peak stress than men (534 vs 507 kdyne/cm2; P<0.0001).
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