Key result
Higher predicted lean mass is linked to ~96% lower risk of severe abdominal aortic calcification.
Why the study?
Evidence concerning the relationship between abdominal aortic calcification and predicted lean mass is limited.
Does predicted lean mass inversely correlate with abdominal aortic calcification in US adults?
Cross-Sectional (n=3,077)
Does predicted lean mass inversely correlate with abdominal aortic calcification in US adults?
Effect estimate: OR 0.04 (95% CI 0.01, 0.20)
p-value: p=<0.001
Higher predicted lean mass is independently associated with lower abdominal aortic calcification scores and a reduced risk of severe calcification in US adults over 40 years old.
Background The association between different body compositions and artery calcification has been proven in several studies. Evidence is still limited concerning abdominal aortic calcification (AAC) and predicted lean mass. This finding examined the relationship between predicted lean mass and abdominal aortic calcification in the United States (US) adults based on 2013–2014 National Health and Nutrition Examination Survey (NHANES). Methods Herein, 3077 respondents were selected from NHANES. Outcome variables were AAC score and severe AAC. We applied survey-weighted multiple regression analysis to examine the correlation between predicted lean mass and AAC. The restricted cubic spline was carried out to depict the linear correlation between predicted lean mass and AAC. Furthermore, we used stratification analysis to find if the correlation of predicted lean mass with severe AAC was sustained across various subclasses. Results Compared to other groups, participants in the first quintile presented higher AAC scores and a higher incidence of severe AAC. The weighted multivariable regression analysis indicated that predicted lean mass showed independent and significant inverse relationships to AAC score and severe AAC (all P < 0.05). Restricted cubic splines observed that the correlation between predicted lean mass and AAC score, AAC severe were linear ( P for non-linearity > 0.05). Relationship between predicted lean mass and severe AAC was still significant in most subclasses. Conclusions Predicted lean mass was adversely and remarkably correlated with AAC in US adults.
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Lai et al. (2023) conducted a cross-sectional in Abdominal aortic calcification (n=3,077). Predicted lean mass (highest quintile) vs. Predicted lean mass (lowest quintile) was evaluated on Severe abdominal aortic calcification (AAC ≥ 6) (OR 0.04, 95% CI 0.01, 0.20, p=<0.001). Higher predicted lean mass was independently and inversely associated with severe abdominal aortic calcification, with the highest quintile showing a significantly reduced risk compared to the lowest (OR 0.04).
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