What question did this study set out to answer?

To determine the role of the CCL2/CCR2 axis in mediating the recruitment of IL-17-producing Th17 and Tc17 cells during allergic airway inflammation.

January 1, 2015International Archives of Allergy and Immunology

CCL2/CCR2-Dependent Recruitment of Th17 Cells but Not Tc17 Cells to the Lung in a Murine Asthma Model

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To determine the role of the CCL2/CCR2 axis in mediating the recruitment of IL-17-producing Th17 and Tc17 cells during allergic airway inflammation.
Sensitized and challenged mice with ovalbumin (OVA) to establish an allergic asthma model.
Administered anti-CCL2 antibody (5 μg/day intratracheally) or CCR2 antagonist RS504393 (2 mg/kg/day intraperitoneally) prior to challenge alongside vehicle and isotype controls.
Measured CCL2 and IL-17 concentrations, Th17 and Tc17 cell frequencies, and histological lung inflammation in lung tissue and bronchoalveolar lavage fluid.
Asthma-modeled mice exhibited marked elevations in CCL2 and IL-17 concentrations alongside increased frequencies of both Th17 and Tc17 cells in lung tissues and bronchoalveolar lavage fluid compared with normal controls.
Inhibition of the CCL2/CCR2 pathway via neutralizing antibodies or receptor antagonism significantly reduced Th17 cell frequency and suppressed airway inflammation without affecting Tc17 cell frequency.

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Implication

Experimental study reveals CCL2/CCR2 signaling recruits Th17 but not Tc17 cells to the lungs in murine asthma, highlighting a distinct pathway for allergic airway inflammation.

Cite This Study

Wang et al. (2015) studied this question.

synapsesocial.com/papers/6a1de419ef3fa0b4c0ef8665 https://doi.org/10.1159/000371764

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Implication

Experimental study reveals CCL2/CCR2 signaling recruits Th17 but not Tc17 cells to the lungs in murine asthma, highlighting a distinct pathway for allergic airway inflammation.

CCL2/CCR2-Dependent Recruitment of Th17 Cells but Not Tc17 Cells to the Lung in a Murine Asthma Model

Key Points

Discussion

Implication

Cite This Study

CCL2/CCR2-Dependent Recruitment of Th17 Cells but Not Tc17 Cells to the Lung in a Murine Asthma Model

Key Points

Discussion

Implication

Cite This Study

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