Population
Rat proximal and distal colon tissue
Comparison
Apical administration of nystatin, basolateral… vs Control conditions
Design
Preclinical
Authors
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No immediate clinical implications; leaves open Ca2+- and cAMP-mediated colonic K+ transport mechanisms for further study.
In the rat colon, an increase in intracellular Ca2+ (via carbachol) stimulates both apical and basolateral K+ conductances, while an increase in cyclic AMP (via forskolin) inhibits basolateral K+ conductance.
Schultheiß et al. (1997) studied this question.
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