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January 16, 2021Journal of Alzheimer s Disease ReportsOpen Access

Neurobiological Pathways Linking Acute Mental Stress to Impairments in Executive Function in Individuals with Coronary Artery Disease

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Why the study?

Individuals with CAD have worse executive function compared to the general population, but the underlying mechanisms remain unknown.

Does acute mental stress affect executive function in individuals with stable coronary artery disease?

Population

389 participants with stable CAD

Comparison

Acute mental stress testing vs baseline

Design

Cohort study

Follow-up

2 years

Authors

KMKasra MoazzamiMWMatthew T. WittbrodtBLBruno B. Lima

Discussion

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Overview

Mental stress responses associated with worse executive function in stable CAD; hypothesis-generating, should not yet change practice.

Structured PICO

Does acute mental stress affect executive function in individuals with stable coronary artery disease?

P
Population
389 individuals with stable coronary artery disease (CAD)
I
Intervention
Acute mental stress (MS) testing
C
Comparator
Baseline (rest)
O
Outcome
Executive function assessed using the Trail Making Test parts A and B at baseline and at 2 years follow-upsurrogate

In patients with stable CAD, acute mental stress induces peripheral vasoconstriction, frontal lobe activation, and inflammatory/sympathetic responses that are associated with worse executive function at 2 years.

Cite This Study

Moazzami et al. (2021) studied this question.

synapsesocial.com/papers/6a1df4cda3f4c58cc9351c8fhttps://doi.org/10.3233/adr-200287
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