What does this research mean for the field?

Angiopoietin 2 (ANGPT2) stimulates TIE2-expressing monocytes (TEMs) to release IL-10, which suppresses T cell proliferation and promotes the expansion of regulatory T cells, acting as a potent immunosuppressive mechanism in tumors. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 3, 2011The Journal of ImmunologyOpen Access

Angiopoietin 2 Stimulates TIE2-Expressing Monocytes To Suppress T Cell Activation and To Promote Regulatory T Cell Expansion

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Structured PICO

Population

In vitro TIE2-expressing monocytes/macrophages (TEMs) and syngeneic murine tumor models

Intervention

Angiopoietin 2 (ANGPT2) stimulation and genetic depletion of tumor TEMs

Comparator

TIE2(-) macrophages and tumors without genetic depletion of TEMs

Outcome

T cell proliferation, ratio of CD4(+) to CD8(+) T cells, and expansion of CD4(+)CD25(high)FOXP3(+) regulatory T cells (Tregs)surrogate

ANGPT2-stimulated TIE2-expressing monocytes act as a potent immunosuppressive force in tumors by releasing IL-10, suppressing T cell activation, and promoting regulatory T cell expansion.

Discussion

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Implication

Preclinical data link ANGPT2-TEM-IL-10 signaling to tumor Treg expansion; leaves open whether targeting TEMs augments immunotherapy in patients.

Cite This Study

Coffelt et al. (2011) studied this question.

synapsesocial.com/papers/6a1df5cf871ff5209bef9a03 https://doi.org/10.4049/jimmunol.1002802

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Implication

Preclinical data link ANGPT2-TEM-IL-10 signaling to tumor Treg expansion; leaves open whether targeting TEMs augments immunotherapy in patients.

Angiopoietin 2 Stimulates TIE2-Expressing Monocytes To Suppress T Cell Activation and To Promote Regulatory T Cell Expansion

Structured PICO

Discussion

Implication

Cite This Study

Angiopoietin 2 Stimulates TIE2-Expressing Monocytes To Suppress T Cell Activation and To Promote Regulatory T Cell Expansion

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider