Why the study?
Does N-acetylcysteine prevent acute renal failure in patients undergoing elective aortic aneurysm repair?
Population
42 patients with stable renal function undergoing elective aortic aneurysm repair.
Comparison
N-acetylcysteine 1200 mg oral twice daily for 24… vs Placebo administered orally for 24 hours before…
Design
RCT, Randomly matched for age, gender, presence of diabetes and pre-existent…
Follow-up
Up to the third post-operative day
Authors
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Clinicians should not use perioperative N-acetylcysteine for renal protection in elective aortic aneurysm repair; this RCT confirms no benefit.
Does N-acetylcysteine prevent acute renal failure in patients undergoing elective aortic aneurysm repair?
Perioperative administration of N-acetylcysteine does not prevent acute renal failure in patients undergoing elective aortic aneurysm repair.
Macedo et al. (2006) studied this question.
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