What does this research mean for the field?

The release of intracellular enzymes, such as lactate dehydrogenase and creatine kinase, from fatigued skeletal muscle is delayed, peaking 1-2 hours after activity, and appears to be initiated by phosphorylcreatine or ATP depletion. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 1, 1983Clinical Science

Release of Intracellular Enzymes from An Isolated Mammalian Skeletal Muscle Preparation

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Population

Isolated mammalian skeletal muscle preparation (fast and slow muscles)

Design

Preclinical

Authors

DJDavid A. JonesNewcastle University MJMalcolm J. JacksonUniversity of Liverpool RER. H. T. EdwardsUniversity of London

Discussion

Member takes

Implication

May inform timing of CK/LDH assessment after muscle stress; leaves open cardiac biomarker mechanisms in humans.

Structured PICO

Population

Isolated mammalian skeletal muscle preparation (fast and slow muscles)

Intervention

Contractile activity, metabolic poisons (cyanide and iodoacetate), and detergent treatment

Outcome

Efflux of enzymes (lactate dehydrogenase and creatine kinase)surrogate

Enzyme release from fatigued isolated skeletal muscle appears to be initiated by phosphorylcreatine or ATP depletion rather than immediate mechanical damage.

Cite This Study

Jones et al. (1983) studied this question.

synapsesocial.com/papers/6a1dfa91e30813deec34e278 https://doi.org/10.1042/cs0650193

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Release of Intracellular Enzymes from An Isolated Mammalian Skeletal Muscle Preparation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Release of Intracellular Enzymes from An Isolated Mammalian Skeletal Muscle Preparation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider