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November 1, 2002Genes & DevelopmentOpen Access

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

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Authors

JCJames ChenUniversity of Central FloridaJTJussi TaipaleUniversity of HelsinkiMCMichael K. CooperBoston University

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Chen et al. (2002) studied this question.

synapsesocial.com/papers/6a1dffab9f4b7580a4ef979chttps://doi.org/10.1101/gad.1025302
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Small molecule modulation of Smoothened activity2002 · 1,014 citations
  2. 2Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.1996 · 385 citations
  3. 3Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists2002 · 493 citations