What does this research mean for the field?

Pharmacological blockade of the slow component of the delayed rectifier current (IKs) fails to significantly lengthen ventricular QTc or action potential duration, indicating it is unlikely to provide antiarrhythmic benefits through these mechanisms. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 2001British Journal of PharmacologyOpen Access

Pharmacological block of the slow component of the outward delayed rectifier current (IKs) fails to lengthen rabbit ventricular muscle QTc and action potential duration

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Why the study?

Does I(Ks) block by chromanol 293B or L-735,821 lengthen QTc and APD compared to I(Kr) block in rabbit ventricular muscle?

Structured PICO

Does I(Ks) block by chromanol 293B or L-735,821 lengthen QTc and APD compared to I(Kr) block in rabbit ventricular muscle?

Population

Rabbit Langendorff-perfused whole hearts, isolated papillary muscle, and single isolated ventricular myocytes

Intervention

I(Ks) block by chromanol 293B (10 microM) or L-735,821 (100 nM)

Comparator

I(Kr) block by E-4031 (100 nM to 1 microM)

Outcome

QTc interval, action potential duration (APD), and membrane currentsurrogate

Pharmacological blockade of I(Ks) fails to lengthen ventricular QTc and APD in rabbit models, suggesting it is unlikely to provide antiarrhythmic benefit via these mechanisms.

Discussion

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Implication

I(Ks) blockade does not prolong repolarization in rabbit ventricle; leaves open whether selective inhibitors confer antiarrhythmic benefit in humans.

Cite This Study

Lengyel et al. (2001) studied this question.

synapsesocial.com/papers/6a1e01fb348274ea529fbe67 https://doi.org/10.1038/sj.bjp.0703777

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Implication

I(Ks) blockade does not prolong repolarization in rabbit ventricle; leaves open whether selective inhibitors confer antiarrhythmic benefit in humans.

Pharmacological block of the slow component of the outward delayed rectifier current (IKs) fails to lengthen rabbit ventricular muscle QTc and action potential duration

Structured PICO

Discussion

Implication

Cite This Study

Pharmacological block of the slow component of the outward delayed rectifier current (IKs) fails to lengthen rabbit ventricular muscle QTc and action potential duration

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider