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July 1, 1975American Journal of Physiology-Legacy Content

Whole-brain blood flow and oxygen metabolism in the rat during nitrous oxide anesthesia

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Authors

AGAlbert GjeddeUniversity of Copenhagen JCJJ CaronnaUniversity of California, Los Angeles BHBengt HindfeltNewYork–Presbyterian Hospital

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Implication

Randomized trial measures whole-brain blood flow and metabolism in rats during nitrous oxide anesthesia, indicating implications for anesthesia techniques.

Key Points

To measure whole-brain blood flow and oxygen metabolism in rats during nitrous oxide anesthesia using the modified Kety-Schmidt technique.
Measured whole-brain blood flow and metabolism in 14 rats using the Kety-Schmidt washout technique.
Simultaneous arterial and venous samples were collected to assess cerebral blood flow (CBF) and oxygen metabolism (CMRO2).
Equilibration of (133)Xe in brain tissue and blood was achieved after 10-24 minutes of inhalation.
Cerebral blood flow (CBF) averaged 98 +/- 6 ml/100 g-min at a mean Paco2 of 40 mmHg.
Cerebral metabolic rate of oxygen (CMRO2) averaged 5.4 +/- 0.7 ml/100 g-min.
CBF increased by 2.4% per mmHg change in Paco2, while CMRO2 showed insignificant changes.

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Gjedde et al. (1975) studied this question.

synapsesocial.com/papers/6a1e0544cd67cee373352342 https://doi.org/10.1152/ajplegacy.1975.229.1.113

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Implication

Randomized trial measures whole-brain blood flow and metabolism in rats during nitrous oxide anesthesia, indicating implications for anesthesia techniques.

Whole-brain blood flow and oxygen metabolism in the rat during nitrous oxide anesthesia

Discussion

Member takes

Implication

Key Points

Cite This Study

Whole-brain blood flow and oxygen metabolism in the rat during nitrous oxide anesthesia

Discussion

Member takes

Implication

Key Points

Cite This Study

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