What question did this study set out to answer?

To determine whether circulating IL-6 mediates acute kidney injury-induced lung damage by triggering lung endothelial CXCL1 expression and neutrophil infiltration.

July 12, 2012AJP Renal Physiology

Circulating IL-6 mediates lung injury via CXCL1 production after acute kidney injury in mice

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Authors

NANilesh AhujaUniversity of Colorado Denver AAAna Andrés-HernandoUniversity of Colorado Anschutz Medical Campus CAChristopher AltmannFlinders University

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Implication

Murine study reveals circulating IL-6 drives lung injury via endothelial CXCL1 after acute kidney injury, indicating IL-6 is a direct pathogenic mediator.

Key Points

To determine whether circulating IL-6 mediates acute kidney injury-induced lung damage by triggering lung endothelial CXCL1 expression and neutrophil infiltration.
Administered recombinant murine IL-6 to IL-6-deficient mice undergoing acute kidney injury (AKI) to test the specific role of systemic IL-6.
Inhibited chemokine signaling using CXCR2-deficient mice and neutralizing anti-CXCL1 antibodies in mouse models of ischemic AKI or bilateral nephrectomy.
Recombinant IL-6 injection into IL-6-deficient mice with AKI significantly increased lung endothelial CXCL1 expression and elevated lung neutrophil infiltration.
Genetic deletion of CXCR2 and antibody inhibition of CXCL1 both resulted in reduced lung neutrophil content following ischemic AKI or bilateral nephrectomy.

Cite This Study

Ahuja et al. (2012) studied this question.

synapsesocial.com/papers/6a1e1354cd67cee37335334e https://doi.org/10.1152/ajprenal.00025.2012

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Implication

Murine study reveals circulating IL-6 drives lung injury via endothelial CXCL1 after acute kidney injury, indicating IL-6 is a direct pathogenic mediator.

Circulating IL-6 mediates lung injury via CXCL1 production after acute kidney injury in mice

Discussion

Member takes

Implication

Key Points

Cite This Study

Circulating IL-6 mediates lung injury via CXCL1 production after acute kidney injury in mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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