What does this research mean for the field?

Proteomic profiling identifies specific protein signatures that can accurately classify soft-tissue sarcoma histological subtypes and differentiate grade III tumors into high- and low-risk prognostic groups. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 30, 2006PROTEOMICS

Proteomic signatures corresponding to histological classification and grading of soft‐tissue sarcomas

View Full Paper

Ask AI

Bookmark

Why the study?

Can proteomic profiling identify biomarkers for the diagnosis, molecular classification, and risk stratification of soft-tissue sarcomas?

Population

80 soft-tissue sarcoma samples with seven different histological backgrounds

Authors

YSYoshiyuki SueharaBrigham and Women's Hospital TKTadashi KondoNational Cancer Center KFKiyonaga FujiiSt. Marianna University School of Medicine

Discussion

Member takes

Implication

May aid sarcoma subtyping and risk stratification; leaves open prospective validation before clinical use.

Structured PICO

Can proteomic profiling identify biomarkers for the diagnosis, molecular classification, and risk stratification of soft-tissue sarcomas?

Population

80 soft-tissue sarcoma samples with seven different histological backgrounds

Intervention

Global protein expression profiling using 2-D difference gel electrophoresis

Outcome

Identification of diagnostic biomarkers and molecular classificationsurrogate

Proteomic profiling can classify soft-tissue sarcomas and identify high-risk grade III patients who may benefit from adjuvant therapy.

Cite This Study

Suehara et al. (2006) studied this question.

synapsesocial.com/papers/6a1e158f79ea62caf66073ca https://doi.org/10.1002/pmic.200600196

View Full Paper

Ask AI

Bookmark

Proteomic signatures corresponding to histological classification and grading of soft‐tissue sarcomas

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Proteomic signatures corresponding to histological classification and grading of soft‐tissue sarcomas

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider