What does this research mean for the field?

Glioblastoma multiforme is most frequently located in the frontal lobe, and while right hemisphere tumors tend to have larger volumes, left hemisphere tumors are associated with a worse prognosis and specific detrimental molecular alterations. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This review aims to examine the lateralization of glioblastoma multiforme and associated molecular alterations across various brain regions.

August 16, 2024Oncology ReportsOpen Access

Glioma lateralization: Focus on the anatomical localization and the distribution of molecular alterations (Review)

View Full Paper

Ask AI

Bookmark

Authors

NÇNilgün Tuncel ÇiniBilecik University MPManuela PennisiUniversity of Catania SGSıdıka GençBilecik University

Discussion

Member takes

Implication

Review reveals the anatomical distribution and molecular changes in glioblastoma across brain regions, indicating important implications for prognosis.

Key Points

This review aims to examine the lateralization of glioblastoma multiforme and associated molecular alterations across various brain regions.
Evaluated anatomical localization of glioblastoma in different brain regions.
Discussed prevalent molecular alterations such as TP53 mutations and EGFR amplification.
Analyzed literature on tumor spread and survival rates in relation to brain lateralization.
GBM is frequently located in the frontal lobe, with specific pathways involved in tumor spread.
Higher tumor volumes were observed in the right hemisphere, whereas poorer prognoses were noted for the left hemisphere.
Key molecular alterations include TP53 mutations, PTEN loss, and MGMT promoter methylation affecting patient outcomes.

Cite This Study

Çini et al. (2024) studied this question.

synapsesocial.com/papers/6a1e19a3c238e2f458353efa https://doi.org/10.3892/or.2024.8798

View Full Paper

Ask AI

Bookmark

Implication

Review reveals the anatomical distribution and molecular changes in glioblastoma across brain regions, indicating important implications for prognosis.

Glioma lateralization: Focus on the anatomical localization and the distribution of molecular alterations (Review)

Discussion

Member takes

Implication

Key Points

Cite This Study

Glioma lateralization: Focus on the anatomical localization and the distribution of molecular alterations (Review)

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider