Continuous-Flow Synthesis of the Fungicide Tetraconazole: Unprecedented Selectivity in Aldol Condensation and Mechanistic Insights via In-Line 200 MHz 1 H NMR

. Crucially, the integration of the water-containing upstream process with the moisture-sensitive reduction was achieved via an efficient in-line liquid-liquid extraction module. This work provides an impactful example of applying sophisticated reactor engineering and mechanistic insight into transform a historically nonselective batch reaction into a high-yielding (up to 74% overall) and fully integrated continuous manufacturing method for a complex pesticide.