Treatment of Zollinger–Ellison Syndrome with Streptozotocin

ALTHOUGH streptozotocin has been used successfully in treatment of malignant insulinomas and carcinoid tumors of the gastrointestinal tract,1 gastrinomas have apparently not been treated with this drug to any great extent. To our knowledge only two cases have been reported, and the results attained were discouraging.2 , 3 The cases reported below concern successful treatment with streptozotocin of two patients with the Zollinger–Ellison syndrome without associated endocrinopathies.Case ReportsCase 1. A 56-year old man had a 15-year history of peptic ulcer and several earlier operations for recurrent ulcers. The diagnosis of the Zollinger–Ellison syndrome, suspected since 1968, was verified by serum . . .