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May 1, 1976Proceedings of the National Academy of SciencesOpen Access

Characterization of a gamma-carboxyglutamic acid-containing protein from bone.

Paul A. Price A A Otsuka James W. Poser J Kristaponis Natarajan Raman

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Abstract

A gamma-carboxyglutamic acid-containing protein has been purified from the calcified tissues of several vertebrates. The presence of three-gamma-carboxyglutamic acid residues in the bovine protein was established by alkaline hydrolysis and amino acid analysis, a method based upon studies with synthetic gamma-carboxyglutamic acid. The identity of gamma-carboxyglutamic acid in the bovine protein was established by mass spectroscopy on the unknown amino acid isolated from alkaline hydrolysates.

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Price et al. (1976) studied this question.

synapsesocial.com/papers/6a1e1d43a3f4c58cc9354ca6 https://doi.org/10.1073/pnas.73.5.1447

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