What question did this study set out to answer?

To determine how antigen-presenting cell-derived cytokines (IL-6, IL-1, and TNF) and CD28 co-stimulation directly modulate the activation and differentiation of naive, Th1, and Th2 CD4 T cells.

January 1, 1998European Journal of Immunology

Augmentation of naive, Th1 and Th2 effector CD4 Responses by IL-6, IL-1 and TNF

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Authors

SJSean B. JosephScripps Research Institute KMKent MinerAmgen (United States)MCMichael CroftLa Jolla Institute for Immunology

Discussion

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Implication

In vitro study demonstrates that IL-6, IL-1, and TNF amplify naive and effector CD4 T cell responses dependent on CD28 co-signaling, indicating that APC cytokines directly boost primed T cell...

Key Points

To determine how antigen-presenting cell-derived cytokines (IL-6, IL-1, and TNF) and CD28 co-stimulation directly modulate the activation and differentiation of naive, Th1, and Th2 CD4 T cells.
Assayed highly purified naive, Th1, and Th2 CD4 T cell populations activated with anti-CD3 antibodies in an APC-free system.
Evaluated the impact of anti-CD28 co-signaling in combination with exogenous IL-6, IL-1, and TNF, administered individually or in combination.
IL-6, IL-1, and TNF enhanced proliferation and IL-2 secretion in naive CD4 T cells strictly in the presence of anti-CD28 co-stimulation, with IL-6 combined with IL-1 or TNF yielding up to an 11-fold increase in IL-2 secretion.
Cytokine exposure did not drive naive T cell differentiation into Th1 or Th2 subsets; IL-6 alone or in combination partially suppressed IFN-gamma-producing cells without inducing IL-4-producing effectors.
Cytokine combinations enhanced cytokine production from pre-existing Th1 and Th2 effector cells—primarily increasing IFN-gamma and IL-5 secretion—to a lesser magnitude than in naive cells.

Cite This Study

Joseph et al. (1998) studied this question.

synapsesocial.com/papers/6a1e1fd366df492de1608e72 https://doi.org/10.1002/(sici)1521-4141(199801)28:01<277::aid-immu277>3.0.co;2-8

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Implication

In vitro study demonstrates that IL-6, IL-1, and TNF amplify naive and effector CD4 T cell responses dependent on CD28 co-signaling, indicating that APC cytokines directly boost primed T cell...

Augmentation of naive, Th1 and Th2 effector CD4 Responses by IL-6, IL-1 and TNF

Discussion

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Implication

Key Points

Cite This Study

Augmentation of naive, Th1 and Th2 effector CD4 Responses by IL-6, IL-1 and TNF

Discussion

Member takes

Implication

Key Points

Cite This Study

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