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Due to the polymorphic nature and leakage of cocoa butter, new bases of greater stability with a melting temperature fairly close to body temperature were investigated. Studies evaluated “shea butter” as a suppository base, especially for tropical uses. The fat is soft at room temperature so it was blended with beeswax to obtain a firm suppository that melts near body temperature and satisfied the pharmaceutical requirement of drug release.
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Ezema et al. (1992) studied this question.
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