What does this research mean for the field?

Pharmacologic activation of aldehyde dehydrogenase 2 (ALDH2) with the small molecule Alda-1 significantly reduces ischemia-induced cardiac damage by inhibiting the formation of cytotoxic aldehydes. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 12, 2008ScienceOpen Access

Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the Heart

View Full Paper

Ask AI

Bookmark

Why the study?

Does Alda-1 reduce infarct size in rat models of cardiac ischemia?

Population

Rodent models (rats) subjected to an ischemic event, and in vitro models of ALDH2*2

Design

Preclinical

Authors

CCChe-Hong ChenStanford Synchrotron Radiation Lightsource GBGrant R. BudasGilead Sciences (United States)ECEric N. ChurchillTakeda (United States)

Discussion

Member takes

Implication

Supports ALDH2 activation for cardioprotection in rodents; hypothesis-generating and should not yet change clinical practice.

Structured PICO

Does Alda-1 reduce infarct size in rat models of cardiac ischemia?

Population

Rodent models (rats) subjected to an ischemic event, and in vitro models of ALDH2*2

Intervention

Alda-1 (small-molecule activator of ALDH2) administered before an ischemic event

Outcome

Infarct sizesurrogate

Pharmacologic activation of ALDH2 with Alda-1 reduces ischemic cardiac damage in rodent models, suggesting a potential therapeutic strategy for myocardial infarction or cardiac surgery.

Cite This Study

Chen et al. (2008) studied this question.

synapsesocial.com/papers/6a1e393740bc8a3dd768a688 https://doi.org/10.1126/science.1158554

View Full Paper

Ask AI

Bookmark

Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the Heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the Heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider