Total Synthesis of (−)‐Episilvestrol and (−)‐Silvestrol

Sugar and spice…︁ The total synthesis of the rare but potent anticancer natural product (−)-episilvestrol and its 5′′′ epimer (−)-silvestrol was accomplished from D-glucose, naringenin, and methyl cinnamate (see scheme). The key steps of the sequence were inspired by the possible biogenesis of these compounds. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z702700_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.