August 1, 2004European Heart Journal

Low incidence of cardiac events with ?-blocking therapy in children with long QT syndrome

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Why the study?

Does beta-blocker therapy prevent cardiac events in children with long QT syndrome?

Structured PICO

Does beta-blocker therapy prevent cardiac events in children with long QT syndrome?

Population

122 children with long QT syndrome (LQTS), including 24 neonates and 98 patients aged 0.5-15 years. Diagnosis was due to syncope (n=51), bradycardia (n=10), or family history (n=61).

Intervention

Beta-blockers, with annual checks by exercise testing and/or 24 h ECG monitoring

Outcome

Cardiac events (death or non-fatal cardiac events)hard clinical

Beta-blocker therapy is associated with a highly favorable outcome and low incidence of cardiac events in children with long QT syndrome, particularly those with KCNQ1 mutations.

Discussion

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Implication

Supports beta-blocker use in pediatric LQTS; leaves open need for randomized confirmation of mutation-specific benefits.

Cite This Study

Villain et al. (2004) studied this question.

synapsesocial.com/papers/6a1e42b040bc8a3dd768aff8 https://doi.org/10.1016/j.ehj.2004.06.016

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Low incidence of cardiac events with ?-blocking therapy in children with long QT syndrome

Structured PICO

Discussion

Implication

Cite This Study

Low incidence of cardiac events with ?-blocking therapy in children with long QT syndrome

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider