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December 30, 2021Medicine & Science in Sports & ExerciseOpen Access

Anabolic Steroids Use Is Associated with Impairments in Atrial and Ventricular Cardiac Structure and Performance in Athletes

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Why the study?

Previous echocardiographic studies on anabolic androgenic steroid use in strength athletes focused on left ventricular strains without evaluating twist mechanics or left atrial function and stiffness.

Does anabolic androgenic steroid use impair left atrial and ventricular structure and function in strength athletes?

Comparison

AAS users vs nonusers vs sedentary controls

Design

Cross-sectional speckle tracking echocardiography study

Authors

AGAntoine GrandperrinUniversité d'Avignon et des Pays de VaucluseISIris SchusterCentre National de la Recherche ScientifiquePMP. MoronvalCentre National de la Recherche Scientifique

Discussion

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Implication

AAS use may impair LA/LV function in athletes; hypothesis-generating for speckle tracking screening, pending prospective data.

Structured PICO

Does anabolic androgenic steroid use impair left atrial and ventricular structure and function in strength athletes?

P
Population
50 subjects including 20 strength-trained young athletes using anabolic androgenic steroids (mean age 32.0 ± 8.5 years), 15 strength-trained athletes with no history of steroid use, and 15 sedentary controls.
I
Intervention
Anabolic androgenic steroids (AAS) use (mean duration 4.7 ± 1.8 years)
C
Comparator
Strength-trained athletes with no history of AAS use (nonusers) and sedentary controls
O
Outcome
Left atrial (LA) and left ventricular (LV) morphology and function assessed by speckle tracking echocardiographysurrogate

Anabolic androgenic steroid use in young strength athletes is associated with significant left atrial and ventricular remodeling and dysfunction, highlighting the potential utility of speckle tracking echocardiography for early screening.

Cite This Study

Grandperrin et al. (2021) studied this question.

synapsesocial.com/papers/6a1e45d040bc8a3dd768b379https://doi.org/10.1249/mss.0000000000002852

Topics

Echocardiography
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increased left atrial chamber stiffness in hypertrophic cardiomyopathy.1993 · 34 citations
  2. 2Left Atrial Function Predicts Heart Failure Hospitalization in Subjects With Preserved Ejection Fraction and Coronary Heart Disease2012 · 153 citations
  3. 3Three-dimensional left ventricular deformation in hypertrophic cardiomyopathy.1994 · 404 citations
  4. 4Anabolic steroids induce cardiac renin-angiotensin system and impair the beneficial effects of aerobic training in rats2007 · 123 citations
  5. 5Influence of the pattern of hypertrophy on left ventricular twist in hypertrophic cardiomyopathy2008 · 56 citations