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Examination of vasopressin concentrations in cerebrospinal fluid continuously withdrawn from free-ranging cats revealed a large daily rhythm, with high concentrations occurring during daylight hours. A similar daily pattern of the peptide was not detected in the circulation. The rhythmic fluctuation of vasopressin in the cerebrospinal fluid further implicates this body fluid as a vehicle of neuroendocrine communication and provides additional evidence that vasopressin may act by means of the cerebrospinal fluid to modulate behavioral processes, such as memory.
Reppert et al. (Fri,) studied this question.
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