What does this research mean for the field?

Somatic mutations in genes such as KCNJ5, ATP1A1, and CACNA1D are not limited to solitary aldosterone-producing adenomas but are also present in multinodular hyperplastic adrenal glands, where typically only a single nodule harbors the mutation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 23, 2014The Journal of Clinical Endocrinology & MetabolismOpen Access

Adrenal Nodularity and Somatic Mutations in Primary Aldosteronism: One Node Is the Culprit?

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Population

53 patients with primary aldosteronism whose adrenal glands were removed due to suspicion of…

Design

Cross-sectional

Authors

TDTanja DekkersRadboud University Nijmegen MMM. ter MeerRadboud University Nijmegen JLJacques W.M. LendersVascular Medicine

Discussion

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Implication

Aldosterone synthase staining may identify culprit nodules in multinodular glands; leaves open whether this refines surgical selection in primary aldosteronism.

Structured PICO

Population

53 patients with primary aldosteronism whose adrenal glands were removed due to suspicion of aldosterone-producing adenomas

Intervention

Histopathological assessment, immunohistochemistry for aldosterone (P450C18) and cortisol (P450C11) synthesis, and genetic sequencing for KCNJ5, ATP1A1, ATP2B3, and CACNA1D mutations in microdissected nodi

Outcome

Multinodularity and phenotypic and genotypic characteristics of the adrenalssurrogate

Somatic mutations driving primary aldosteronism are not limited to solitary adenomas but also occur in multinodular adrenals, typically localized to a single aldosterone-producing nodule.

Cite This Study

Dekkers et al. (2014) studied this question.

synapsesocial.com/papers/6a1e5f90e86bee794c409cba https://doi.org/10.1210/jc.2013-4255

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Implication

Aldosterone synthase staining may identify culprit nodules in multinodular glands; leaves open whether this refines surgical selection in primary aldosteronism.

Adrenal Nodularity and Somatic Mutations in Primary Aldosteronism: One Node Is the Culprit?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Adrenal Nodularity and Somatic Mutations in Primary Aldosteronism: One Node Is the Culprit?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider