Population
H295R cells and Xenopus oocytes
Comparison
Introduction of the novel somatic KCNJ5 mutation… vs Wild-type KCNJ5 sequences
Design
Preclinical
Authors
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DelI157 effects in animal models extend prior KCNJ5 selectivity data; human validation required before clinical relevance.
The novel KCNJ5 mutation delI157 found in aldosterone-producing adenomas depolarizes the cell and reduces cation selectivity, similar to previously reported selectivity filter mutations.
Murthy et al. (2012) studied this question.
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