What does this research mean for the field?

Isolated rat adrenal glomerulosa and fasciculata cells function as highly sensitive potassium sensors and exhibit a voltage-dependent calcium regenerative response characteristic of excitable cells. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 1, 1987Endocrinology

Electrical Properties of Isolated Rat Adrenal Glomerulosa and Fasciculata Cells*

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Population

Isolated rat adrenal glomerulosa and fasciculata cells

Design

Preclinical

Authors

SQS. J. QuinnAdvocate Christ Medical Center MCM. Carter CornwallBoston University GWGordon H. WilliamsPreventive Cardiology

Discussion

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Implication

May guide studies on Ca2+-dependent steroidogenesis; leaves open human relevance and clinical translation.

Structured PICO

Population

Isolated rat adrenal glomerulosa and fasciculata cells

Intervention

Intracellular voltage-recording and constant current stimulation, with manipulation of external ion concentrations (K+, Na+, Ca2+, Sr2+, Ba2+, Mn2+, Co2+)

Outcome

Passive and active electrical properties (resting membrane potential, response to ion concentration changes, regenerative response)surrogate

Rat adrenal glomerulosa and fasciculata cells exhibit electrical properties common to excitable cells, including a voltage-dependent Ca2+ regenerative response that may be involved in secretagogue stimulation of steroidogenesis.

Cite This Study

Quinn et al. (1987) studied this question.

synapsesocial.com/papers/6a1c3737d54006be995fb8a6 https://doi.org/10.1210/endo-120-3-903

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Electrical Properties of Isolated Rat Adrenal Glomerulosa and Fasciculata Cells*

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Electrical Properties of Isolated Rat Adrenal Glomerulosa and Fasciculata Cells*

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider