In an in vitro mouse model, alpha-mimetic agents, vasopressin, and angiotensin II depolarized juxtaglomerular cells, suggesting they may inhibit renin secretion via increased calcium influx, while isoproterenol likely increases renin secretion independently of membrane potential changes.
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Alpha-agonists, AVP, and Ang II may inhibit renin via JG depolarization in mice; hypothesis-generating and requires in vivo human validation before any clinical inference.
Bührle et al. (1985) studied this question.
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