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June 20, 2005Nephrology Dialysis TransplantationOpen Access

Electrophysiology of the renin-producing juxtaglomerular cells

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Population

Single isolated juxtaglomerular (JG) cells from mice (n=106) and rats (n=192)

Comparison

Pharmacological manipulation of ion channels and… vs Control solutions

Design

Preclinical

Authors

UFUlla G. FriisBJBoye L. JensenFJFinn Jørgensen

Discussion

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Overview

Should not yet inform clinical renin modulation; extends exocytotic mechanisms in animal JG cells.

Structured PICO

P
Population
Single isolated juxtaglomerular (JG) cells from mice (n=106) and rats (n=192)
I
Intervention
Pharmacological manipulation of ion channels and cyclic nucleotide pathways (including cAMP, cGMP, trequinsin, and various channel blockers) using patch-clamp technique and superfusion
C
Comparator
Control solutions
O
Outcome
Membrane conductance (current-voltage relationship), cell capacitance (Cm) as a measure of exocytosis, and renin releasesurrogate

This preclinical study elucidates the electrophysiological properties of juxtaglomerular cells, demonstrating that renin secretion is an exocytotic process regulated by cAMP and cGMP pathways and specific potassium and calcium channels.

Cite This Study

Friis et al. (2005) studied this question.

synapsesocial.com/papers/6a7da9213fa445558d7d8484https://doi.org/10.1093/ndt/gfh857
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Control of Renin Secretion From Rat Juxtaglomerular Cells by cAMP-Specific Phosphodiesterases2002 · 83 citations
  2. 2Membrane potential and cation channels in rat juxtaglomerular cells2004 · 20 citations
  3. 3Cyclic AMP selectively increases renin mRNA stability in cultured juxtaglomerular granular cells.1993 · 102 citations
  4. 4Angiotensin II induces oscillations of intracellular calcium and blocks anomalous inward rectifying potassium current in mouse renal juxtaglomerular cells.1989 · 134 citations
  5. 5Cellular mechanism of renin release2004 · 74 citations