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May 17, 2002Circulation ResearchOpen Access

Control of Renin Secretion From Rat Juxtaglomerular Cells by cAMP-Specific Phosphodiesterases

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Population

Isolated rat juxtaglomerular (JG) cells

Design

Preclinical

Authors

UFUlla G. FriisBJBoye L. JensenSSShala Sethi

Discussion

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Overview

Hypothesis-generating for PDE3/4 regulation of renin; does not yet inform clinical renin-angiotensin strategies.

Structured PICO

P
Population
Isolated rat juxtaglomerular (JG) cells
I
Intervention
PDE3 inhibitors (trequinsin, milrinone), PDE4 inhibitor (rolipram), cAMP, and cGMP
O
Outcome
Renin release, cellular cAMP content, cell membrane capacitance (Cm), and outward currentsurrogate

Degradation of cAMP by PDE3 and PDE4 regulates renin release from juxtaglomerular cells, providing cellular evidence that cGMP stimulates renin release via PDE3 inhibition.

Cite This Study

Friis et al. (2002) studied this question.

synapsesocial.com/papers/6a81f4e1ac3bbfe76d610147https://doi.org/10.1161/01.res.0000017622.25365.71
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endogenous or overexpressed cGMP-dependent protein kinases inhibit cAMP-dependent renin release from rat isolated perfused kidney, microdissected glomeruli, and isolated juxtaglomerular cells1998 · 77 citations
  2. 2Regulation of Renin Secretion and Renin Synthesis by Second Messengers in Isolated Mouse Juxtaglomerular Cells1991 · 50 citations
  3. 3Cyclic AMP selectively increases renin mRNA stability in cultured juxtaglomerular granular cells.1993 · 102 citations
  4. 4Stimulation of renin secretion by nitric oxide is mediated by phosphodiesterase 31998 · 101 citations
  5. 5Role of Phosphodiesterase Isoenzymes in the Control of Renin Secretion: Effects of Selective Enzyme Inhibitors1999 · 6 citations