Population
Primary culture of juxtaglomerular (JG) cells isolated from C-57/B6 mice
Comparison
Incubation for 2 hours with 100 micromol/L of… vs Incubation without BAPTA-AM
Design
Preclinical
Follow-up
2 hours
Authors
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Highlights calcium-AC signaling in renin release; leaves open translation to human JG cell physiology.
Decreased intracellular calcium stimulates renin release in juxtaglomerular cells by activating calcium-inhibitable isoforms of adenylyl cyclase (types V and/or VI).
Ortiz‐Capisano et al. (2006) studied this question.
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