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December 27, 2006Hypertension

Adenylyl Cyclase Isoform V Mediates Renin Release From Juxtaglomerular Cells

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Population

Primary cultures of juxtaglomerular cells isolated from C-57/B6 mice at 70% to 80% confluence

Comparison

Cytosolic calcium chelator BAPTA-AM and… vs Negative controls and baseline measurements

Design

Preclinical

Authors

MOM. Cecilia Ortiz‐CapisanoPOPablo A. OrtizPHPamela Harding

Discussion

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Overview

May link juxtaglomerular calcium to renin via adenylyl cyclase-V in animals; leaves open human relevance and therapeutic targeting.

Structured PICO

P
Population
Primary cultures of juxtaglomerular cells isolated from C-57/B6 mice at 70% to 80% confluence
I
Intervention
Cytosolic calcium chelator BAPTA-AM (100 micromol/L) and selective adenylyl cyclase-V inhibitor NKY80
C
Comparator
Negative controls and baseline measurements
O
Outcome
cAMP formation and renin releasesurrogate

Lowering intracellular calcium in juxtaglomerular cells increases adenylyl cyclase-V activity, producing cAMP and stimulating renin secretion.

Cite This Study

Ortiz‐Capisano et al. (2006) studied this question.

synapsesocial.com/papers/6a856a3cfc70cb81dc202709https://doi.org/10.1161/01.hyp.0000255172.84842.d2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Decreased Intracellular Calcium Stimulates Renin Release via Calcium-Inhibitable Adenylyl Cyclase2006 · 79 citations
  2. 2The Calcium Paradoxon of Renin Release2006 · 81 citations
  3. 3Cyclic AMP increases cytoplasmic free calcium in renin-secreting cells from rat kidney2009
  4. 4Importance of calcium in renal renin release1986 · 17 citations
  5. 5Calcium-dependent phosphodiesterase 1C inhibits renin release from isolated juxtaglomerular cells2009 · 40 citations