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February 1, 2011HypertensionOpen Access

Stimulation of plasma renin concentration by isoproterenol was significantly attenuated in AC5(-/-) (male: -20%; female: -33%) and more pronounced in AC6(-/-) (male: -63%; female: -50%) compared with wild-type mice.

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Why the study?

Does the knockout of adenylyl cyclases 5 and 6 reduce catecholamine-stimulated renin secretion in mice?

Population

AC5(-/-) and AC6(-/-) knockout mice, and wild-type mice

Comparison

Isoproterenol, prostaglandin E2, and pituitary… vs Wild-type mice (AC5(+/+) and AC6(+/+))

Design

Preclinical

Authors

FAFadi AldehniTTTong TangKMKirsten Madsen

Discussion

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Overview

Hypothesis-generating for AC isoform-selective renin modulation; requires human validation before clinical consideration.

Structured PICO

Does the knockout of adenylyl cyclases 5 and 6 reduce catecholamine-stimulated renin secretion in mice?

P
Population
AC5(-/-) and AC6(-/-) knockout mice, and wild-type mice
I
Intervention
Isoproterenol (10 mg/kg IP single injection), prostaglandin E2, and pituitary adenylyl cyclase-activating polypeptide
C
Comparator
Wild-type mice (AC5(+/+) and AC6(+/+))
O
Outcome
Plasma renin concentration and renin synthesissurrogate

Both AC5 and AC6 are involved in the stimulation of renin secretion in vivo, with AC6 being the dominant isoform.

Cite This Study

Aldehni et al. (2011) studied this question.

synapsesocial.com/papers/6a83fa30f72f0ca72062d38fhttps://doi.org/10.1161/hypertensionaha.110.167130
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Calcium Paradoxon of Renin Release2006 · 81 citations
  2. 2Adenylyl Cyclase Isoform V Mediates Renin Release From Juxtaglomerular Cells2006 · 62 citations
  3. 3Decreased Intracellular Calcium Stimulates Renin Release via Calcium-Inhibitable Adenylyl Cyclase2006 · 79 citations
  4. 4The Inhibition of Renin Secretion by Alpha-Adrenergic Stimulation in the Isolated Rat Kidney1974 · 62 citations
  5. 5Adenosine inhibits renin release from juxtaglomerular cells via an A<sub>1</sub>receptor-TRPC-mediated pathway2013 · 22 citations