Endogenous adenosine acts on the A1 receptor to restrain renin release induced by activation of intrarenal beta-adrenoceptors, without counteraction by A2 receptor activation.
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A1 receptor blockade augments beta-adrenergic renin release in this model; leaves open whether selective A1 antagonism alters renin-angiotensin activation in human cardiorenal disease.
Pfeifer et al. (1995) studied this question.
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