Why the study?
Do A1 adenosine receptor antagonists alter cardiovascular and renal function in anesthetized rats?
Do A1 adenosine receptor antagonists alter cardiovascular and renal function in anesthetized rats?
A1 adenosine receptor antagonists induce significant diuresis and natriuresis via a renal tubular mechanism without altering hemodynamics or potassium homeostasis in rats.
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A1 antagonists may offer a hemodynamically neutral diuretic approach in rats; leaves open translation to human cardiovascular disease.
Kuan et al. (1993) studied this question.
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