What is the clinical evidence from this study?

Population: Congestive heart failure (n=20). Intervention: BG9719 (A1 receptor blockade) vs. Vehicle only. Primary outcome: Creatinine clearance (p=<0.05).

What question did this study set out to answer?

This research aims to define the effects of A1 receptor inhibition on cardiac and renal functions in congestive heart failure.

October 1, 2001Journal of Cardiovascular Pharmacology

Effects of Adenosine Receptor Subtype A 1 on Ventricular and Renal Function

Q: What are the key findings of this study?

Selective A1 receptor blockade with BG9719 improved creatinine clearance (127 vs 62 ml/min, p<0.05) and induced natriuresis and diuresis in a pig model of CHF without adverse cardiac effects.

Q: What question did this study set out to answer?

This research aims to define the effects of A1 receptor inhibition on cardiac and renal functions in congestive heart failure.

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Key result

Selective A1 receptor blockade with BG9719 improved creatinine clearance (127 vs 62 ml/min, p<0.05) and induced natriuresis and diuresis in a pig model of CHF without adverse cardiac effects.

Why the study?

Does A1 receptor blockade improve renal function and hemodynamics in a pig model of congestive heart failure?

Key Points

This research aims to define the effects of A1 receptor inhibition on cardiac and renal functions in congestive heart failure.
10 pigs with pacing-induced congestive heart failure (CHF) were assessed at 240 bpm for 3 weeks.
A1 receptor blockade was administered using 100 microg of BG9719 or vehicle in a randomized manner.
Hemodynamic measures and renal function indices including urine output and creatinine clearance were monitored.
Heart rate, mean aortic pressure, and left ventricular peak pressure rose following A1 blockade in CHF pigs.
Urine output doubled and sodium clearance tripled post A1 blockade (p < 0.05).
Creatinine clearance improved with blockade (127 +/- 17 vs. 62 +/- 7 ml/min, p < 0.05).

Structured PICO

Does A1 receptor blockade improve renal function and hemodynamics in a pig model of congestive heart failure?

Population

20 pigs with pacing-induced congestive heart failure evaluated for systemic hemodynamics and renal function.

Intervention

A1 receptor blockade with 100 microg of BG9719 (1,3-dipropyl-8-[2-(5,6-epoxynorbornyl)]xanthene)

Comparator

Infusion of vehicle only

Outcome

Systemic hemodynamics and indices of renal function (including heart rate, mean aortic pressure, left ventricular peak pressure, cardiac output, vascular resistance, urine output, sodium clearance, and creatinine clearance)surrogate

Main Result

Absolute Event Rate: 127% vs 62%

p-value: p=<0.05

Selective A1 receptor blockade improves glomerular filtration rate, diuresis, and natriuresis without adverse cardiac effects in a preclinical model of heart failure.

Discussion

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Implication

Supports renal benefits of A1 blockade in porcine HF; leaves open human efficacy and safety trials.

Cite This Study

Lucas et al. (2001) studied Congestive heart failure (n=20). BG9719 (A1 receptor blockade) vs. Vehicle only was evaluated on Creatinine clearance (p=<0.05). Selective A1 receptor blockade with BG9719 improved creatinine clearance (127 vs 62 ml/min, p<0.05) and induced natriuresis and diuresis in a pig model of CHF without adverse cardiac effects.

synapsesocial.com/papers/6a20b48852a81c8a3de52354 https://doi.org/10.1097/00005344-200110000-00014

Topics

HFrEF treatment Heart failure

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Effects of Adenosine Receptor Subtype A 1 on Ventricular and Renal Function

Key Points

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Topics

Effects of Adenosine Receptor Subtype A 1 on Ventricular and Renal Function

Key Points

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider